By H. Arnouk

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Extra info for Advancements in Tumor Immunotherapy, Cancer Vaccines

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If a patient fails these early stage therapies or has advanced stages of prostate cancer, he undergoes hormonal therapies. Unfortunately, not all hormonal therapy is effective in eliminating malignant cells, and eventually all patients reach castration-resistant prostate cancer levels. , 2009). , 2006). However, docetaxel is cell-cycle specific, which means that it is cytotoxic to all dividing cells and not just tumor cells. Patients who take docetaxel are likely to experience neutropenia, anemia, neuropathy, alopecia, and nail damage.

However, the process of the approval at the advisory meeting has been conflicting, and required clarification of the approval standards. As the initial discussion at the committee indicated that the data “failed to establish the efficacy” of Provenge, the wording of the question was altered in mid-vote asking whether the sponsor had provided “substantial evidence” of efficacy. This resulted in the vote swing for several members of the advisory panel, and the Committee voted 13 to 4 to recommend Provenge's approval (Goldberg, 2007b).

2006). MVA-5T4induced immune responses are an early marker of efficacy in renal cancer patients. Cancer Immunolology, Immunotherapy, Vol. 60, No. , & Harrop R. (2009). Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-alpha. Journal of Immunotherapy, Vol. 32, No. W. (2009). Integrated data from 2 randomized, double-blind, placebocontrolled, phase 3 trials of active cellular immunotherapy with sipuleucel-t in advanced prostate cancer.

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